Endothelial cells come together to form a barrier between vessels and tissues. These cells control the flow of substances and fluid into and out of the blood vessels. These cells are present in all the vasculature of our body, including the heart, brain, liver, intestine, spleen, and kidney, to name a few. When these cells have dysfunction, they can lead to serious health issues throughout the body. Studying these cells is of utmost necessity to understand how they regulate the transportation of substances and in the formation of new blood vessels. But, that is not the only thing they do! Endothelial cells are also used in other tests to understand how they interact with drugs. The permeability of endothelial cells varies from organ to organ, with the least permeability in the brain to the most relaxed permeability in the liver. When we compare endothelial vs. epithelial cells, we find that both cells have a similar function as they both serve as a barrier to foreign substances.
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